Everything You Need To Know About Kratom Alkaloids

Kratom is a popular herbal supplement that has been used for centuries in traditional medicine. This guide provides an overview of the alkaloids found in kratom and discusses their potential benefits and side effects.

Mitragynine Chemical Structure

Are you interested in learning about kratom alkaloids? Then read on! Kratom is a tropical evergreen tree found in Southeast Asia, and for centuries, its leaves have been used for medicinal and recreational purposes. But what makes kratom so powerful? The answer lies in its unique chemistry: the active compounds in kratom are called alkaloids. In this article, we’ll discuss what these alkaloids are and how they affect the body.

Kratom alkaloids come from mitragynine and 7-hydroxymitragynine, two of the main components of kratom leaves. They interact with mu-opioid receptors in the brain to create various effects on the user. This includes pain relief and sedation, as well as increased energy levels and improved mood. Kratom alkaloids can also help reduce anxiety, stress, and depression – all without the negative side effects of prescription drugs.

So if you’re looking for natural ways to improve your physical and mental wellbeing, then understanding kratom alkaloids is a must. Get ready to explore this fascinating plant medicine!

What Are Kratom Alkaloids?

Kratom alkaloids are the active ingredients in the leaves of the kratom tree, Mitragyna speciosa. Kratom alkaloids have been used traditionally for centuries by cultures in Southeast Asia to treat various conditions, but they have recently become more popular in Western countries. Studies have shown that kratom alkaloids have a variety of effects on the human body, depending on the dosage and concentration of alkaloids present.

The most significant kratom alkaloid is mitragynine, which makes up around 66% of total alkaloid content. The other major alkaloid is 7-hydroxymitragynine, which comprises about 2% of total alkaloid content. There are also several minor alkaloids present in kratom leaves, including paynantheine, speciogynine, and corynantheidine. All of these different types of kratom alkaloids interact with receptors in the brain to produce their effects.

The effects of kratom vary depending on the concentration and type of alkaloid present in the leaves. Lower concentrations tend to produce stimulant-like effects while higher concentrations tend to produce sedative-like effects. Additionally, some users report feeling more relaxed or energized when taking different types of kratom strains. For this reason, it’s important to research different strains before trying them out so you can find one that works best for you.

Kratom has become increasingly popular as an alternative treatment for a variety of conditions such as pain relief and anxiety reduction. However, it’s important to remember that there is still limited research available on its long-term effects and safety profile. As with any substance or supplement, it’s always best to consult your doctor before using it so that you can get an accurate diagnosis and safe treatment plan for any health concern you may have.

Types Of Kratom Alkaloids

Kratom alkaloids are complex chemical compounds that are found in the leaves of the kratom tree. They are part of what gives kratom its unique effects when consumed. In this article, we’ll explore the various types of alkaloids present in kratom and how they contribute to its effects.

The primary alkaloid in kratom is mitragynine, which makes up around 66% of the total alkaloid content. This is the compound responsible for many of kratom’s pain-relieving and mood-enhancing properties. Other alkaloids include 7-hydroxymitragynine, speciogynine, paynantheine, and others, which vary from strain to strain. Each one contributes to a slightly different effect profile when ingested together with mitragynine.

Apart from these two major alkaloids, there are also several minor ones that play a role in how kratom affects the body. These include rhynchophylline, corynantheidine, and speciofoline. They interact with each other synergistically to produce an overall effect that is greater than the sum of its parts. Research has shown that these minor alkaloids can help reduce inflammation, improve mental clarity and focus, as well as provide anti-anxiety effects.

It’s important to note that all of these alkaloids have their own individual effects on the body; however, it’s only when taken together that their combined effects become truly powerful. Different strains of kratom will contain different ratios of these alkaloids; thus creating a variety of potential outcomes depending on which type you choose to use. With so many options available, it’s no wonder why millions around the world have been drawn to this natural remedy!

Alkaloids of Kratom and their role:

The general action of the alkaloids has been explained. We will further look into the various alkaloids present in Kratom and their modes of action.


This alkaloid is the one that is most widely known by the general public. The reason for it being known better is the abundance of the alkaloid in every strain of Kratom. Almost all strains have at least 65-70% Mitragynine in their leaves. The alkaloid is of great importance to scientists and has been studied on numerous occasions in isolation. This alkaloid interacts with the opioid receptors present in your central nervous system. It creates a feeling of well-being, happiness, and relaxation. Furthermore, it has analgesic properties.


Extensive research into the working of this particular alkaloid is currently underway. However, we do know that Paynantheine is the second most abundant alkaloid present in Mitragyna leaves. Many studies claim that Paynantheine might be inactive to a great extent in the human body.


Although less in concentration than several other alkaloids in Kratom, 7-Hydroxymitragynine is one of the most active alkaloids when working in the human body. It is infamous because of the analgesic effects the alkaloid has. 7-Hydroxymitragynine has often been called the critical component of Kratom. Studies have shown that this alkaloid may be responsible for the pain-killing effects. It acts by interacting with the opioid receptors of the brain.


By concentration, this alkaloid is the third most abundant alkaloid present in most Mitragyna strains. Speciogynine is an alkaloid with a lot of future potentials. It is active in the human body and is believed to have sedative and pain-relieving effects.

These four alkaloids are some of the most abundant and well-known alkaloids of Mitragyna. However, it is believed that there are more than 40 different alkaloids present in the Kratom plants. Some of these alkaloids have yet to be discovered by scientists. Other alkaloids of the Mitragyna plant include Mitraphylline, Ajmalicine, and more. These chemical agents have considerable potential in research and studies.

How does alkaloid concentration in various products vary?

Several factors can affect the alkaloid concentration of your Kratom products. One of the most significant factors is the origin of that particular Mitragyna strain. Every geographical area can have slightly varying alkaloid content of their Kratom trees because of the different growing conditions in that region.

Harvest time and cultivation and procuring techniques can also affect the alkaloid concentration in your final product. However, the biggest factor that comes into play is the type of product you are buying.

If you opt for regular Kratom powders and capsules of great quality, you will feel a regulated and mellow effect that stays with you until your next dose. These products are best suited for beginners and people just starting their Mitragyna journey. On the other hand, if you buy premium Kratom powders or extracts online, the alkaloid concentration in these products will be comparatively higher. Therefore, you will get a stronger hit from these products. Furthermore, the doses of both these kinds of products need to be controlled so that you do not end up taking the wrong dose. The type of product you opt for depends upon your requirements, needs, and preferences at the end.

Benefits Of Kratom Alkaloids

Kratom alkaloids offer a variety of benefits for those who use them. As with any supplement, it’s important to consult your doctor before using them. This is especially true if you’re pregnant or nursing, as there may be risks associated with taking kratom alkaloids.

The primary benefits of kratom alkaloids are their pain and stress-relieving properties. They can help to reduce inflammation, improve moods, and calm the nervous system. Kratom alkaloids can also act as an appetite suppressant, helping individuals to maintain healthy eating habits. Additionally, they may act as an energy booster, allowing users to feel more energized throughout the day.

Kratom alkaloids have been used for centuries in traditional medicine systems around the world. Research has shown that they are safe and effective when taken in small doses. Some people have reported experiencing mild side effects such as nausea, dizziness, and headaches after taking kratom alkaloids; however, these symptoms usually disappear after a few days of use.

Overall, kratom alkaloids offer a range of potential health benefits for those who choose to use them safely and appropriately. It’s important to remember that each individual may respond differently to this type of supplement; therefore it’s best to consult your doctor before taking any new supplements or medications.

How Kratom Alkaloids Work

Kratom alkaloids are important compounds that make up the plant Mitragyna speciosa, more commonly known as kratom. These alkaloids interact with the body in different ways to provide a number of benefits. But how do they work? This article will explore how these alkaloids act on the body to produce their effects.

The primary active alkaloid in kratom is mitragynine, which binds to opioid receptors in the brain and produces analgesic and sedative effects. It also stimulates serotonin and dopamine production in the brain, resulting in improved mood and relaxation. Additionally, several other alkaloids present in kratom interact with various neurotransmitters, including norepinephrine and acetylcholine, which can help to improve focus and cognitive function.

When taken orally, kratom alkaloids are absorbed into the bloodstream through the digestive system. From there, they cross through the blood-brain barrier and bind to their respective targets in the brain or elsewhere in the body. Depending on their target actions and concentrations, these compounds can produce a wide range of effects on mental and physical health. Studies have also shown that some of these alkaloids may have anti-inflammatory properties as well as antioxidant activity.

Kratom has become increasingly popular due to its potential therapeutic benefits, but it’s important to remember that while it may be beneficial for some people, it’s not necessarily safe for everyone. It’s always best to consult a healthcare professional before trying any new supplement or herbal remedy. With proper knowledge of how kratom works on our bodies – its potential risks as well as its possible benefits – we can make an informed decision about whether this plant is right for us.

Side Effects Of Kratom Alkaloids

Kratom alkaloids are known for their unique effects on the body, but there can be some side effects to consider as well. To understand these potential issues more deeply, it’s important to take a closer look at how kratom alkaloids interact with the body and what consequences they might have.

One of the most common side effects of kratom alkaloids is nausea. Because they interact directly with the opioid receptors in the brain, they can trigger a feeling of queasiness or even vomiting. Additionally, because kratom alkaloids can cause a decrease in blood pressure, those taking them may experience lightheadedness or dizziness. Some users have also reported feeling excessive fatigue or sedation after using kratom alkaloids.

It’s worth noting that not all users will experience these side effects – in fact, many people don’t experience any at all. However, if someone does feel any of these symptoms after taking kratom alkaloids, it’s important to stop consuming them and speak with a doctor as soon as possible. While there haven’t been any reports of long-term health risks associated with taking kratom alkaloids, it’s best to err on the side of caution and consult with an expert before continuing usage.

Overall, while kratom alkaloids offer numerous benefits, it’s important to be aware of their potential side effects and how they may affect your body. If you do decide to use them, make sure you discuss your plans with your doctor first and monitor your body for any adverse reactions that might occur afterwards.

Common Uses Of Kratom Alkaloids

Kratom alkaloids have a variety of uses, some more common than others. They can be taken in a variety of forms such as capsules, powder, and even liquid extract. Kratom alkaloids are often used to treat pain and anxiety, and they may also help with opioid withdrawal symptoms. Additionally, they can be used to boost energy and improve mood.

One of the most common uses of kratom alkaloids is as a natural pain reliever. It has been found to be particularly effective for chronic pain conditions like fibromyalgia. Many people also report that it helps them cope with headaches, joint pain, and muscle soreness. Additionally, it is sometimes used as an alternative to over-the-counter or prescription medications for treating depression or anxiety.

Kratom alkaloids are also used to increase focus and productivity by providing mental clarity and improved concentration levels. They are often taken before studying or working on difficult projects because they provide an extra boost of energy that helps get things done quickly and efficiently. Additionally, many people find that kratom alkaloids can reduce stress levels which makes it easier to stay focused on tasks without getting overwhelmed.

Kratom alkaloids are becoming increasingly popular due to their wide range of potential benefits. With the right dosage and preparation method, they can provide relief from physical pain as well as mental clarity while improving overall wellbeing at the same time. For those looking for natural remedies with few side effects, kratom alkaloids may be worth considering.

Kratom Alkaloid Dosage

When it comes to kratom alkaloids, the dosage you should take is of utmost importance. While there is no universal dose for everyone, understanding the basics about dosing kratom alkaloids can help you find what works best for you. There are a few things to keep in mind when determining your ideal dosage.

For starters, it’s important to understand the strain of kratom you’re using and its effects on your body. Different strains can have different levels of potency, so understanding how it will affect your body is essential. Additionally, individual factors such as body weight, age, and health can also play a role in determining the right dosage for you. With this in mind, it’s best to start with a low dose and gradually increase as needed.

When dosing kratom alkaloids, remember that they are most effective when taken on an empty stomach. Taking them with food or other substances may reduce their effectiveness or even cause adverse reactions. It’s also important to be aware of any potential side effects such as nausea or headache that may occur after taking them. If these occur, immediately stop taking them and consult a doctor if necessary.

Overall, dosing kratom alkaloids correctly is key for getting the most out of them. Be sure to do your research and find what works best for you by starting with a low dose and increasing gradually if needed while being mindful of any potential side effects that may occur. Ultimately, this will help ensure safe and successful use of these powerful compounds.

Factors Affecting Kratom Alkaloid Potency

When considering kratom alkaloids, there are a few factors that can affect potency. In this section, we’ll discuss these factors and how they influence the efficacy of kratom’s alkaloid content.

One major factor affecting kratom alkaloid potency is the type of strain used. Different strains have different concentrations of alkaloids, so it’s important to consider when selecting a strain for desired effects. For instance, some strains contain more mitragynine than 7-hydroxymitragynine while others have higher concentrations of both compounds. This means that some strains will be more potent than others depending on the purpose they’re being used for.

Another factor that can influence kratom alkaloid potency is the way in which it is prepared and consumed. If it is boiled or brewed into a tea, the boiling process can reduce the amount of active ingredients in the leaves due to water evaporation. Similarly, if kratom powder is ingested directly, it may not be as effective as other methods like capsules or tinctures because some of the active ingredients may be broken down by stomach acid before reaching their full potential in the body.

Finally, another factor that affects kratom alkaloid potency is how long it has been stored. Kratom should be stored in an airtight container away from direct sunlight and heat to preserve its full potency over time. Keeping it stored properly will ensure that its alkaloid levels remain consistent and effective when consumed.

In summary, there are several factors affecting kratom alkaloid potency including type of strain used, preparation method and storage conditions. By understanding these factors and how they play a role in determining efficacy, users can choose a strain and method that will provide them with their desired results safely and effectively.

Kratom Alkaloid Supplements

Kratom alkaloid supplements are becoming increasingly popular among those looking for relief from a variety of ailments. While many people are already aware of the therapeutic effects of kratom, understanding how to get the most out of these compounds is essential in order to maximize their benefits. To this end, it’s important to understand the different kratom alkaloid supplements available and how they can help you achieve your desired results.

Kratom alkaloid supplements come in several varieties, including capsules, powders, and tinctures. Each supplement has its own unique concentration levels of various alkaloids, making them suitable for various needs. For example, some people may find capsules containing higher concentrations of certain kratom alkaloids to be more effective for their specific needs than powders or tinctures with lower concentrations. Additionally, some manufacturers offer products that have been specifically designed to provide a consistent dosage each time you take it.

No matter which type of supplement you choose, it’s important to keep in mind that individual responses can vary greatly when taking kratom alkaloid supplements due to differences in body chemistry and metabolism. Therefore, it’s best to start with a smaller dose and adjust accordingly until you find what works best for you. Additionally, if possible, try to find a reputable supplier who carries products that have been tested for purity and potency by third-party laboratories. Taking these steps will ensure that you’re getting the highest quality product that’s right for your individual needs.

By understanding your options when it comes to kratom alkaloid supplements and taking steps to ensure quality control, you can maximize the therapeutic potential of this natural plant medicine and experience its full range of beneficial effects.

Safety Of Kratom Alkaloids

When it comes to safety, kratom alkaloids are relatively safe when taken in small doses. However, the risks associated with larger doses of these alkaloids can be serious. It’s important to understand the potential dangers of consuming too much kratom in order to stay safe and healthy.

Kratom contains over 25 different alkaloids, each of which can have an effect on the body and mind depending on how much is consumed. These effects can range from mild stimulation to strong sedation or euphoria. Long-term use of high dosages has been linked to liver toxicity, respiratory depression, and other serious health issues. For this reason, it’s important not to exceed the recommended dosage and consult with a healthcare professional before taking any supplements containing kratom alkaloids.

Although there isn’t a great deal of long-term research into the safety of using kratom alkaloid supplements, it’s generally believed that they are fairly safe when taken as directed. Many people find them helpful for managing pain, anxiety, and depression symptoms but it’s always best to talk with your doctor before beginning any new supplement regimen. With proper care and caution, kratom alkaloid supplements can be an effective way to support your mental health and overall wellbeing.

Frequently Asked Questions


In conclusion, kratom alkaloids have a variety of potential benefits that may be helpful for those dealing with pain and anxiety. The legality of kratom alkaloids varies from state to state, so it’s important to be aware of the laws in your area. Additionally, there is evidence that suggests taking kratom alkaloids long-term can cause adverse reactions, so it is best to consult with a healthcare professional before using them. Finally, as with any new supplement, it’s important to speak with your doctor about any interactions between kratom alkaloids and prescription medications you may be taking. I hope this article has provided you with all the information you need to make an informed decision about whether or not kratom alkaloids are right for you.

Shopping Cart
Are you 21 years of age?
We require that you are of 21 years of age to purchase our products.
This product is not for use by or sale to persons under the age of 21. This product should be used only as directed on the label. Consult with a physician before use if you have a serious medical condition or use prescription medications. A Doctor’s advice should be sought before using this and any supplemental dietary product. All trademarks and copyrights are property of their respective owners and are not affiliated with nor do they endorse this product. These statements have not been evaluated by the FDA. This product is not intended to diagnose, treat, cure or prevent any disease. By using this site, you agree to follow the Privacy Policy and all Terms & Conditions printed on this site. Void Where Prohibited by Law. Due to recent laws passed in Alabama, Arkansas, Indiana, Tennessee, Vermont and Wisconsin, we do not ship to these areas. For respect to foreign and domestic laws, we will not ship to areas where Kratom is deemed illegal.